Protein Purification
MilliporeSigma™ Calbiochem™ Calmodulin Inhibitory Peptide
The Calmodulin Inhibitory Peptide controls the biological activity of Calmodulin. This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ Pamidronate, Disodium Salt
A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.
Thermo Scientific™ CaptureSelect™ LC-lambda (mouse) Affinity Matrix
Thermo Scientific™ CaptureSelect™ LC-lambda (mouse) Affinity Matrix contains a 13 kDa recombinant single domain antibody fragment (VHH affinity ligand) recognizing the lambda light chain of mouse Ig's.
MilliporeSigma™ Calbiochem™ TTNPB
A synthetic stilbene analog of retinoic acid that acts as a potent retinoic acid receptor (RAR) agonist (EC50 = 21 nM, 4.0 nM, and 2.4nM for RARα, RARβ, and RARγ, respectively).
MilliporeSigma™ Calbiochem™ Zonisamide
An antiepileptic agent that blocks voltage-dependent Na(+) channels and T-type Ca(2+) channels.
MilliporeSigma™ Calbiochem™ Caspase-3 Inhibitor II
The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Deoxyhypusine Synthase Inhibitor, GC7
The Deoxyhypusine Synthase Inhibitor, GC7, also referenced under CAS 150333-69-0, controls the biological activity of Deoxyhypusine Synthase.
MilliporeSigma™ Calbiochem™ Cyclopamine-KAAD
Cyclopamine- KAAD, CAS 306387-90-6, is a cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM).
MilliporeSigma™ Calbiochem™ VEGFR Tyrosine Kinase Inhibitor VI, AAL-993
The VEGFR Tyrosine Kinse Inhibitor VI, ALL-993, also referenced under CAS 269390-77-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Casein Kinase II Inhibitor I
The Casein Kinase II Inhibitor I, also referenced under CAS 17374-26-4, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ RIP1 Inhibitor II, 7-Cl-O-Nec-1
RIP1 Inhibitor II, 7-Cl-O-Nec-1, CAS 852391-15-2, is a cell-permeable, highly selective RIP1 inhibitor. Blocks RIP1-dependent necroptosis (EC50 = 206nM in Jurkat cells).
MilliporeSigma™ Calbiochem™ MMP Inhibitor III
The MMP Inhibitor III, also referenced under CAS 927827-98-3, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Pravastatin, Sodium Salt
A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ≈1 nM).
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor III
A cell-permeable benzothiazolylchromenone compound that disrupts Skp2-Skp1 interaction via direct Skp2 affinity binding and selectively prevents Skp2-, but not Fbw7- or β-TrCP-, Skp1-Cullin-1-F-box (SFC) complex-mediated substrates ubiquitination, effectively preventing Skp2 substrates activation (Akt) and degradation (p21 & p27) with concomitant down-regulation of cellular Skp2 protein level (10 to 20μM in HEK293T & PC3 cultures)
MilliporeSigma™ Calbiochem™ Bisindolylmaleimide I, Hydrochloride
An enhanced water-soluble form of Bisindolylmaleimide I.